1) prefix conveying the idea of difficulty, opposition, injuriousness, similar to our "mis-" or "un-" prefixes
Part of Speech: particle
G1418
A primary inseparable particle of uncertain derivation; used only in composition as a prefix; hard, that is, with difficulty: - + hard, + grievous, etc.
These two sites give similar information, with the definition from several dictionaries and statistics on the use of the word.
University of Chicago's Logion lexicon
Thayer's dictionary plus other information.
From this site's dictionary (in Italian)
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Click on the first column to search for that word as a form of the root δυς; click on the second column to search for that grammatical form of the root δυς; click on the third column to search for that word and grammatical form; click on the total to search for the root δυς.